SCHEMBL8369882

SCHEMBL8369882

C1=NO1.O=C(O)C(COc1cccnc1Cl)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.40
CYP2C19 P33261 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
LMNA P02545 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
CASP3 P42574 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36
SENP6 Q9GZR1 1/20 0.36
HTR1D P28221 2/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.34
ALDH1A1 P00352 1/20 0.34
RAB9A P51151 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8369947 0.78 CHRNB2 (0.34) POLBCYP2C19CYP1A2CYP2C9KMT2A
SCHEMBL8195092 0.77 MEN1 (0.52) POLBCYP2C19CYP1A2SMN1; SMN2HTR1D
SCHEMBL7543571 0.74 TSHR (0.46) CYP1A2CYP2C9LMNASMN1; SMN2KMT2A
SCHEMBL8181049 0.71 ALDH1A1 (0.44) POLBCYP2C19CYP1A2LMNASMN1; SMN2
SCHEMBL30680090 0.69 PTGDR2 (0.53) POLBCYP2C19CYP1A2CYP2C9LMNA
SCHEMBL16741104 0.69 PTGDR2 (0.53) POLBCYP2C19CYP1A2CYP2C9LMNA
SCHEMBL7539626 0.68 SCN4A (0.52) CYP1A2LMNAKMT2AMEN1NPC1
SCHEMBL18228678 0.68 SCN4A (0.53) POLBCYP2C19LMNAKMT2AMEN1
SCHEMBL20897965 0.68 CHRNB2 (0.48) CYP2C19CYP1A2LMNASMN1; SMN2L3MBTL1
SCHEMBL20897976 0.68 CHRNB2 (0.48) CYP2C19CYP1A2LMNASMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617011-B1 Process for producing alkoxyiminoacetamide compounds SHIONOGI & CO (JP) 1999-01-20 EP disclosed
US-5506358-A USEFUL AS AGRICULTURAL FUNGICIDES SHIONOGI & CO., LTD. (JP) 1996-04-09 US disclosed
EP-0617011-A2 Process for producing alkoxyiminoacetamide compounds SHIONOGI & CO., LTD. (JP) 1994-09-28 EP disclosed