Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3070290 | 0.82 | HDAC3 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1511329 | 0.80 | HDAC3 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1395758 | 0.80 | HDAC3 (0.44) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL11336506 | 0.79 | BRD4 (0.47) | HDAC4HDAC7HDAC5CES2CES1 | |
| SCHEMBL5684986 | 0.79 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL11753976 | 0.78 | CES2 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1398583 | 0.78 | HDAC3 (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL27845968 | 0.77 | HDAC3 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8657004 | 0.77 | SMN1; SMN2 (0.42) | CES2CES1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9558442 | 0.77 | CES2 (0.45) | HDAC4HDAC7HDAC5CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110041316-A | TAM family kinase/and CSF1R kinase inhibitor and application thereof | 南京药捷安康生物科技有限公司 | 2019-07-23 | — | — | CN | disclosed |
| CN-109575018-A | A kind of anti-infective compounds | 韩国巴斯德研究所 | 2019-04-05 | — | — | CN | disclosed |
| CN-106103439-B | 2,7- diaza spiro [3.5] nonane compound | 瑞敏德股份有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-109414421-A | The inhibitor and its application method of indole amine 2,3-dioxygenase | 百时美施贵宝公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-108440370-A | Inhibitors of viral replication | 鲁汶天主教大学 | 2018-08-24 | — | — | CN | disclosed |
| CN-104024223-B | Inhibitors of viral replication | 鲁汶天主教大学 | 2018-07-24 | — | — | CN | disclosed |
| CN-108191746-A | A kind of novel hydroxyl pyridine compounds and preparation method and application | 暨南大学 | 2018-06-22 | — | — | CN | disclosed |
| CN-107820492-A | Pyridin-3-yl acetic acid derivatives as inhibitors of HIV replication | VIIV保健英国第五有限公司 | 2018-03-20 | — | — | CN | disclosed |
| CN-103980219-B | A kind of novel bacterial quorum sensing regulator and medical application thereof | 中国人民解放军军事医学科学院毒物药物研究所 | 2016-12-28 | — | — | CN | disclosed |
| CN-106103439-A | 2,7 diaza spiros [3.5] nonane compound | 瑞敏德股份有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-101128199-A | Monocyclic heterocycles as kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2008-02-20 | — | — | CN | disclosed |
| CN-101005843-A | Pyrrolotriazine kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2007-07-25 | — | — | CN | disclosed |
| CN-1993130-A | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2007-07-04 | — | — | CN | disclosed |
| WO-2007017261-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |
| WO-2007017262-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |
| CN-1671386-A | Substituted anilinic piperidines as MCH selective antagonists | LUNDBECK & CO AS H (DK) | 2005-09-21 | — | — | CN | disclosed |
| CN-1668300-A | Spirocyclic piperidines as MCH1 antagonists and uses thereof | LUNDBECK & CO AS H (DK) | 2005-09-14 | — | — | CN | disclosed |
| CN-1642600-A | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines | PROCTER & GAMBLE (US) | 2005-07-20 | — | — | CN | disclosed |
| US-5032588-A | Non-steroidal antiinflammatory | ABBOTT LABORATORIES (US) | 1991-07-16 | — | — | US | disclosed |
| WO-1991008744-A1 | THIAZOLE LIPOXYGENASE-INHIBITING COMPOUNDS DERIVED FROM NON-STEROIDAL ANTIINFLAMMATORY CARBOXYLIC ACIDS | ABBOTT LABORATORIES (US) | 1991-06-27 | — | — | WO | disclosed |