Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368524 | 0.84 | MAPT (0.58) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9795519 | 0.84 | MAPT (0.58) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL6685970 | 0.81 | KDM4E (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL14459434 | 0.76 | KMT2A (0.74) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL19638131 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9795561 | 0.75 | NTRK1 (0.57) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9338885 | 0.75 | MAPT (0.62) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL5561958 | 0.75 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL31093984 | 0.75 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL9871765 | 0.75 | ALDH1A1 (0.67) | SMN1; SMN2ALDH1A1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0910358-A1 | PHENYL DERIVATIVES USEFUL AS BLOCKERS OF CHLORIDE CHANNELS | NEUROSEARCH A/S (DK) | 1999-04-28 | — | — | EP | disclosed |
| EP-0693053-B1 | UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS | NEUROSEARCH AS (DK) | 1999-01-20 | — | — | EP | disclosed |
| US-5696138-A | Urea derivatives and their use | NEUROSEARCH A/S (DK) | 1997-12-09 | — | — | US | disclosed |
| WO-1997045111-A1 | PHENYL DERIVATIVES USEFUL AS BLOCKERS OF CHLORIDE CHANNELS | NEUROSEARCH A/S (DK) | 1997-12-04 | — | — | WO | disclosed |
| EP-0693053-A1 | UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994022807-A1 | UREA AND AMIDE DERIVATIVES AND THEIR USE IN THE CONTROL OF CELL MEMBRANE POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 1994-10-13 | — | — | WO | disclosed |