Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PNMT | P11086 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30117130 | 0.85 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL27671576 | 0.84 | PPARG (0.53) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8370289 | 0.81 | SMN1; SMN2 (0.56) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30645113 | 0.81 | KMT2A (0.51) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8227131 | 0.79 | MEN1 (0.50) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27690525 | 0.79 | PNMT (0.49) | MEN1KMT2ASMN1; SMN2ALDH1A1POLB | |
| Tert-Butylamine SCHEMBL27690523 | 0.79 | PPARG (0.49) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27690520 | 0.77 | PNMT (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL8281830 | 0.76 | ALDH1A1 (0.64) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13434151 | 0.76 | ALDH1A1 (0.64) | KDM4EMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461026-A2 | METHOD FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003047513-A2 | METHOD FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2003-06-12 | — | — | WO | disclosed |
| WO-2001046140-A1 | EP4 RECEPTOR SELECTIVE AGONISTS IN THE TREATMENT OF OSTEOPOROSIS | PFIZER PRODUCTS INC. (US) | 2001-06-28 | — | — | WO | disclosed |