Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.52 |
| ▸ | PRKX | P51817 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.52 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8369527 | 0.90 | CDC7 (0.53) | CDC7PLK4DAPK3ROCK2CHEK2 | |
| SCHEMBL8369802 | 0.88 | CDC7 (0.48) | CDC7PLK4DAPK3ROCK2CHEK2 | |
| SCHEMBL8369762 | 0.88 | PLK1 (0.69) | CDC7PLK4DAPK3ROCK2CHEK2 | |
| SCHEMBL8369755 | 0.88 | PLK1 (0.69) | CDC7PLK4DAPK3ROCK2CHEK2 | |
| SCHEMBL8870428 | 0.86 | ROCK1 (0.49) | CDC7PLK4DAPK3ROCK2CHEK2 | |
| SCHEMBL8870420 | 0.86 | ROCK1 (0.49) | CDC7PLK4DAPK3ROCK2CHEK2 | |
| SCHEMBL8369736 | 0.85 | DAPK3 (0.44) | CDC7PLK4DAPK3ROCK2CHEK2 | |
| SCHEMBL8369737 | 0.85 | DAPK3 (0.44) | CDC7PLK4DAPK3ROCK2CHEK2 | |
| SCHEMBL8369858 | 0.78 | MGLL (0.43) | CDC7PLK4DAPK3ROCK2CHEK2 | |
| SCHEMBL8371877 | 0.77 | PLK1 (0.56) | CDC7PLK4DAPK3ROCK2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796243-B1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PROD (US) | 1999-01-27 | — | — | EP | claimed |
| EP-0796243-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-09-24 | — | — | EP | claimed |
| WO-1996015103-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-05-23 | — | — | WO | claimed |
| US-5464867-A | SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-11-07 | — | — | US | claimed |
| EP-0796243-B1 | DIAMINOCYCLOBUTENE-3,4-DIONES | AMERICAN HOME PROD (US) | 1999-01-27 | — | — | EP | disclosed |
| US-5536741-A | SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-16 | — | — | US | disclosed |
| US-5536731-A | SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-07-16 | — | — | US | disclosed |
| US-5530025-A | SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-25 | — | — | US | disclosed |