SCHEMBL8373232

SCHEMBL8373232

CCCC(CCC)C(=O)NCC(=O)OC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BIRC2 Q13490 1/20 0.58
HDAC7 Q8WUI4 2/20 0.52
HDAC8 Q9BY41 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
HDAC9 Q9UKV0 2/20 0.52
HDAC5 Q9UQL6 2/20 0.52
TET2 Q6N021 1/20 0.50
HDAC1 Q13547 3/20 0.45
HDAC2 Q92769 2/20 0.45
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45
RECQL P46063 1/20 0.44
CHRM1 P11229 1/20 0.41
AKR1A1 P14550 1/20 0.41
CHRM3 P20309 1/20 0.41
HTR2A P28223 1/20 0.41
HTR2C P28335 1/20 0.41
ADRA1A P35348 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20991859 0.85 BIRC2 (0.73) BIRC2TET2RECQLCA1CA2
SCHEMBL21914636 0.85 BIRC2 (0.73) BIRC2TET2RECQLCA1CA2
SCHEMBL23235630 0.85 BIRC2 (0.73) BIRC2TET2RECQLCA1CA2
SCHEMBL23801208 0.82 BIRC2 (0.64) BIRC2TET2RECQLTSHRCA1
SCHEMBL4017322 0.79 HDAC7 (0.56) HDAC7HDAC8HDAC6HDAC9HDAC5
SCHEMBL13374821 0.79 HDAC7 (0.56) BIRC2HDAC7HDAC8HDAC6HDAC9
Valrocemide SCHEMBL4014030 0.78 HDAC7 (0.54) BIRC2HDAC7HDAC8HDAC6HDAC9
SCHEMBL10433522 0.77 BIRC2 (0.44) BIRC2HDAC7HDAC8HDAC6HDAC9
SCHEMBL7734253 0.77 BIRC2 (0.44) BIRC2TET2RECQL
SCHEMBL26296395 0.76 HDAC7 (0.62) HDAC7HDAC8HDAC6HDAC9HDAC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100457720-C 2-propyl valeramide and 2-propyl pentaenuylamide derivative and application used as anti-convulsion medicine YISSUM RES DEV CO (IL) 2009-02-04 CN disclosed
CN-1418869-A 2-propyl valeramide and 2-propyl pentaenuylamide derivative and application used as anti-convulsion medicine YISSUN RES DEV CO OF THE HEBRE (IL) 2003-05-21 CN disclosed
CN-1106379-C 2-propylvaleramide and 2-propylpentenamide derivatives and their use as anticonvulsants YISSUM RES DEV CO (IL) 2003-04-23 CN disclosed
EP-0659174-B1 DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS YISSUM RES DEV CO (IL) 1999-02-10 EP disclosed
US-5585358-A ANTIEPILEPTIC AGENTS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; DYSKINESIA; ANTIISCHEMIC AGENTS YISSUM RESEARCH DEVELOPMENT CORPORATION OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1996-12-17 US disclosed
CN-1111907-A 2-propylvaleramide and 2-propylpentenamide derivatives and their use as anticonvulsants YISSUM RES DEV CO (IL) 1995-11-15 CN disclosed
EP-0659174-A4 DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS. YISSUM RES DEV CO (IL) 1995-09-27 EP disclosed
EP-0659174-A1 DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1995-06-28 EP disclosed
WO-1995001956-A1 DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 1995-01-19 WO disclosed