Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376338 | 0.82 | KMT2A (0.59) | ALDH1A1RAB9ANPC1MAPTKMT2A | |
| SCHEMBL9422578 | 0.77 | KMT2A (0.68) | POLBHDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL10975265 | 0.73 | POLB (0.63) | POLBHDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL16000906 | 0.72 | ALDH1A1 (0.64) | POLBALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL10866673 | 0.71 | RAB9A (0.49) | POLBHDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL8094674 | 0.71 | CUL4A (0.43) | POLBALDH1A1USP2HSD17B10MAPT | |
| SCHEMBL8745445 | 0.70 | MEN1 (0.36) | POLBALDH1A1USP2RAB9ANPC1 | |
| SCHEMBL4610426 | 0.69 | KMT2A (0.54) | POLBHDAC1HDAC7HDAC8HDAC6 | |
| SCHEMBL3928807 | 0.69 | ALDH1A1 (0.67) | ALDH1A1RAB9ANPC1MAPTKMT2A | |
| SCHEMBL11440992 | 0.69 | POLB (0.62) | POLBHDAC1HDAC7HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590458-B1 | Substituted thiophene carboxylic acid amides | BAYER AG (DE) | 1999-02-24 | — | — | EP | disclosed |
| EP-0590458-A1 | Substituted thiophene carboxylic acid amides | BAYER AG (DE) | 1994-04-06 | — | — | EP | disclosed |