Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8372308 | 0.76 | HSD17B10 (0.59) | HSD17B10ELANEAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL8375398 | 0.75 | HSD17B10 (0.62) | HSD17B10AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL8044565 | 0.72 | HSD17B10 (0.57) | HSD17B10AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL7595533 | 0.69 | NOTUM (0.47) | ELANENOTUMALOX15 | |
| SCHEMBL9174491 | 0.69 | HSD17B10 (0.43) | HSD17B10NOTUMAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL31668173 | 0.66 | AKR1C4 (0.55) | HSD17B10AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL8055911 | 0.66 | AKR1C4 (0.55) | HSD17B10AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL3070779 | 0.66 | NOTUM (0.47) | ELANENOTUMALOX15 | |
| SCHEMBL9173276 | 0.66 | HTT (0.47) | HSD17B10 | |
| SCHEMBL21824325 | 0.65 | TPMT (0.50) | HSD17B10ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669940-B1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | UNIV TORONTO (CA) | 1999-02-10 | — | — | EP | disclosed |
| US-5399671-A | Specifically crosslinked hemoglobin with free functionality | UNIVERSITY OF TORONTO INNOVATIONS FOUNDATION, THE (CA) | 1995-03-21 | — | — | US | disclosed |