SCHEMBL837451

SCHEMBL837451

COC(=O)Cc1ccc(Cl)cc1Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.56
HTT P42858 2/20 0.56
KDM4E B2RXH2 1/20 0.56
KMT2A Q03164 2/20 0.55
L3MBTL1 Q9Y468 2/20 0.55
MEN1 O00255 1/20 0.55
THRB P10828 1/20 0.55
MAPT P10636 1/20 0.53
RECQL P46063 1/20 0.52
TDP1 Q9NUW8 2/20 0.51
GAA P10253 2/20 0.51
HDAC3 O15379 1/20 0.51
HDAC4 P56524 1/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC7 Q8WUI4 1/20 0.51
HDAC2 Q92769 1/20 0.51
HDAC10 Q969S8 1/20 0.51
HDAC11 Q96DB2 1/20 0.51
HDAC8 Q9BY41 1/20 0.51
HDAC6 Q9UBN7 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1525623 0.98 ALDH1A1 (0.54) ALDH1A1HTTKDM4EKMT2AL3MBTL1
SCHEMBL7133160 0.86 MAPT (0.49) ALDH1A1HTTKDM4EKMT2AL3MBTL1
SCHEMBL28688295 0.85 KMT2A (0.55) ALDH1A1HTTKDM4EKMT2AL3MBTL1
SCHEMBL11260961 0.85 KMT2A (0.55) ALDH1A1HTTKDM4EKMT2AL3MBTL1
SCHEMBL4711040 0.84 ALDH1A1 (0.51) ALDH1A1HTTKDM4EKMT2AL3MBTL1
SCHEMBL10923842 0.84 ALDH1A1 (0.50) ALDH1A1HTTKDM4EKMT2AL3MBTL1
SCHEMBL20521859 0.84 MEN1 (0.47) ALDH1A1HTTKDM4EKMT2AL3MBTL1
SCHEMBL30581858 0.84 ALDH1A1 (0.51) ALDH1A1HTTKDM4EKMT2AL3MBTL1
SCHEMBL9610136 0.84 ALDH1A1 (0.42) ALDH1A1HTTKDM4EKMT2AL3MBTL1
SCHEMBL28068586 0.84 MAPT (0.44) ALDH1A1HTTKDM4EKMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-220159929-U Mixing device for preparing 2, 4-dichlorophenylacetic acid methyl ester 安徽云帆药业有限公司 2023-12-12 CN claimed
CN-116969900-A Preparation process of 2- (2, 4-dichlorophenyl) -3- (1-H, 1,2, 4-triazolyl) propanol 安徽云帆药业有限公司 2023-10-31 CN claimed
CN-219849507-U Quantitative dosing device for preparing 2, 4-dichlorophenylacetic acid methyl ester 安徽云帆药业有限公司 2023-10-20 CN claimed
CN-101987854-A Preparation method of clopidogrel and salts thereof BEIJING VENTUREPHARM TECHNOLOGY CO LTD 2011-03-23 CN claimed
US-12162882-B2 Quinolone derivatives as fibroblast growth factor receptor inhibitors PRINCIPIA BIOPHARMAC, INC. (US) 2024-12-10 US disclosed
CN-118702710-A Method for synthesizing organoboron compound by visible light catalysis 常州大学 2024-09-27 CN disclosed
US-20240092777-A1 Quinolone Derivatives as Fibroblast Growth Factor Receptor Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2024-03-21 US disclosed
CN-220159929-U Mixing device for preparing 2, 4-dichlorophenylacetic acid methyl ester 安徽云帆药业有限公司 2023-12-12 CN disclosed
CN-220159929-U Mixing device for preparing 2, 4-dichlorophenylacetic acid methyl ester 安徽云帆药业有限公司 2023-12-12 CN disclosed
CN-220159929-U Mixing device for preparing 2, 4-dichlorophenylacetic acid methyl ester 安徽云帆药业有限公司 2023-12-12 CN disclosed
CN-219996583-U Sampling detection device in preparation process of 2- (2, 4-dichlorophenyl) methyl acrylate 安徽云帆药业有限公司 2023-11-10 CN disclosed
CN-116969900-A Preparation process of 2- (2, 4-dichlorophenyl) -3- (1-H, 1,2, 4-triazolyl) propanol 安徽云帆药业有限公司 2023-10-31 CN disclosed
WO-2002087573-A1 CRF RECEPTOR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2002-11-07 WO disclosed
WO-2002088095-A1 FUSED PYRIMIDINES AS ANTAGONISTS OF THE CORTICOTROPIN RELEASING FACTOR (CRF) GLAXO GROUP LIMITED (GB) 2002-11-07 WO disclosed
EP-1218359-A2 PIPERAZINE COMPOUNDS GLAXO GROUP LIMITED (GB) 2002-07-03 EP disclosed
WO-2001025219-A2 PIPERAZINE COMPOUNDS GLAXO GROUP LIMITED (GB) 2001-04-12 WO disclosed
WO-1996015672-A1 FUNGICIDAL COMPOSITION ZENECA LIMITED (GB) 1996-05-30 WO disclosed
WO-1996015671-A1 HERBICIDES ZENECA LIMITED (GB) 1996-05-30 WO disclosed
US-4598085-A Fungicidal 1-(2-aryl-2-R-ethyl)-1H-1,2,4-triazoles JANSSEN PHARMACEUTICA N.V. (BE) 1986-07-01 US disclosed
EP-0099165-A1 Triazole and imidazole compounds, process for their preparation and their use as fungicides and plant growth regulators, and intermediates for their synthesis IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-01-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12162882-B2 Quinolone derivatives as fibroblast growth factor receptor inhibitors FGFR1, FGFR3, FGFR2 ALDH1A1 1116/4885HTT 3490/4885KDM4E 2775/4885
US-20240092777-A1 Quinolone Derivatives as Fibroblast Growth Factor Receptor Inhibitors FGFR1, FGFR3, FGFR2 ALDH1A1 1116/4885HTT 3490/4885KDM4E 2775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.