Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375893 | 0.81 | STAT3 (0.56) | ACHEBACE1AURKASTAT3PDGFRB | |
| SCHEMBL8374536 | 0.79 | PDE5A (0.50) | ACHEBACE1ENPP1PDE10APDE1B | |
| SCHEMBL8378420 | 0.75 | NEK2 (0.53) | ACHEBACE1PDGFRBENPP1PDE1B | |
| SCHEMBL8377010 | 0.75 | PDE5A (0.48) | ACHEBACE1ENPP1PDE10APDE1B | |
| SCHEMBL8374694 | 0.74 | KDM4E (0.65) | ACHEBACE1ENPP1PDE1BMAPK1 | |
| Hydrochloric Acid SCHEMBL8374707 | 0.74 | PDE5A (0.47) | ACHEBACE1ENPP1PDE10APDE1B | |
| Hydrochloric Acid SCHEMBL8379494 | 0.74 | PDE5A (0.55) | ACHEBACE1AURKAENPP1PDE10A | |
| SCHEMBL8377033 | 0.73 | MAPK1 (0.73) | ENPP1MAPK1 | |
| SCHEMBL8374872 | 0.73 | PDE5A (0.51) | ACHEBACE1ENPP1PDE10APDE1B | |
| Hydrochloric Acid SCHEMBL8375179 | 0.73 | PDE5A (0.54) | ACHEBACE1AURKAENPP1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990117-A | Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives | CELL PATHWAYS, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5614627-A | Quinazoline compounds | EISAI CO., LTD. (JP) | 1997-03-25 | — | — | US | disclosed |