Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.56 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378420 | 0.84 | NEK2 (0.53) | ALDH1A1HSD17B10PDGFRBKDM4EMAPK1 | |
| SCHEMBL8374694 | 0.83 | KDM4E (0.65) | LMNAALDH1A1HSD17B10KDM4EMAPK1 | |
| SCHEMBL8375167 | 0.81 | RPS6KB1 (0.52) | STAT3PDGFRBMAPK1ACHEBACE1 | |
| SCHEMBL8377033 | 0.79 | MAPK1 (0.73) | LMNAKMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL8374536 | 0.79 | PDE5A (0.50) | ALDH1A1HSD17B10KDM4EMAPK1ACHE | |
| SCHEMBL8377010 | 0.75 | PDE5A (0.48) | ALDH1A1HSD17B10KDM4EMAPK1ACHE | |
| SCHEMBL2071493 | 0.74 | HPGDS (0.55) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8374707 | 0.74 | PDE5A (0.47) | ALDH1A1HSD17B10KDM4EMAPK1ACHE | |
| Hydrochloric Acid SCHEMBL8379494 | 0.74 | PDE5A (0.55) | LMNAALDH1A1SMN1; SMN2HTTHSD17B10 | |
| SCHEMBL10704614 | 0.74 | HSD11B1 (0.55) | HSD11B1LMNAKMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990117-A | Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives | CELL PATHWAYS, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5614627-A | Quinazoline compounds | EISAI CO., LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0669324-A1 | QUINAZOLINE COMPOUND | Eisai Co., Ltd. (JP) | 1995-08-30 | — | — | EP | disclosed |