Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31668173 | 0.98 | AKR1C4 (0.55) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL8055911 | 0.98 | AKR1C4 (0.55) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| Potassium SCHEMBL8375396 | 0.97 | AKR1C4 (0.53) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL17627594 | 0.79 | AKR1C4 (0.60) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL13171452 | 0.76 | CA12 (0.39) | MEN1HTTKMT2AEGFRLCK | |
| SCHEMBL3842336 | 0.76 | L3MBTL1 (0.41) | MEN1HTTKMT2AALDH1A1MAPK1 | |
| SCHEMBL7860222 | 0.76 | PTPN2 (0.50) | KDM4EMEN1HTTKMT2AALDH1A1 | |
| SCHEMBL26477685 | 0.75 | AKR1C4 (0.41) | AKR1C4AKR1C3AKR1C2AKR1C1KDM4E | |
| SCHEMBL8143660 | 0.75 | HPGD (0.56) | KDM4EMEN1HTTKMT2ALMNA | |
| SCHEMBL20140708 | 0.75 | LCK (0.38) | KDM4EMAPTEGFRLCKCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669940-B1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | UNIV TORONTO (CA) | 1999-02-10 | — | — | EP | disclosed |
| EP-0669940-A1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | THE UNIVERSITY OF TORONTO INNOVATIONS FOUNDATION (CA) | 1995-09-06 | — | — | EP | disclosed |
| US-5399671-A | Specifically crosslinked hemoglobin with free functionality | UNIVERSITY OF TORONTO INNOVATIONS FOUNDATION, THE (CA) | 1995-03-21 | — | — | US | disclosed |
| WO-1994011399-A1 | SPECIFICALLY CROSSLINKED HEMOGLOBIN WITH FREE FUNCTIONALITY | KLUGER RONALD (CA) | 1994-05-26 | — | — | WO | disclosed |