SCHEMBL8375599

SCHEMBL8375599

Cc1c(C)c(-c2ccccc2)c(C)c(C)c1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SENP1 Q9P0U3 1/20 0.50
PDE4B Q07343 4/20 0.48
PDE4A P27815 3/20 0.48
PDE4C Q08493 3/20 0.48
PDE4D Q08499 3/20 0.48
HDAC4 P56524 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
LMNA P02545 2/20 0.40
MAPT P10636 2/20 0.40
HTT P42858 1/20 0.40
MMP3 P08254 1/20 0.40
BCL2L1 Q07817 1/20 0.40
KMT2A Q03164 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CHEK1 O14757 1/20 0.39
AKT2 P31751 1/20 0.39
BRD4 O60885 1/20 0.39
BRD2 P25440 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28193538 0.95 SENP1 (0.46) SENP1PDE4BPDE4APDE4CPDE4D
SCHEMBL32679359 0.90 PDE4B (0.48) SENP1PDE4BPDE4APDE4CPDE4D
SCHEMBL28949416 0.88 SENP1 (0.54) SENP1PDE4BPDE4APDE4CPDE4D
SCHEMBL9701635 0.87 LMNA (0.50) SENP1PDE4BPDE4APDE4CPDE4D
SCHEMBL5589126 0.86 SENP1 (0.58) SENP1PDE4BPDE4APDE4CPDE4D
SCHEMBL28248289 0.86 SENP1 (0.58) SENP1PDE4BPDE4APDE4CPDE4D
SCHEMBL28962158 0.85 PDE4B (0.54) SENP1PDE4BPDE4APDE4CPDE4D
SCHEMBL14968792 0.85 SENP1 (0.42) SENP1PDE4BPDE4APDE4CPDE4D
SCHEMBL8618279 0.84 LMNA (0.48) SENP1PDE4BPDE4APDE4CPDE4D
SCHEMBL19956864 0.83 PDE4B (0.52) SENP1PDE4BPDE4APDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659801-B1 Polyimide MITSUI CHEMICALS INC (JP) 1999-03-10 EP disclosed
US-5484880-A HEAT RESISTANT POLYMERS FOR APPLIANCES AND INJECTION MOLDED ARTICLES OR FILMS MITSUI TOATSU CHEMICALS, INC. (JP) 1996-01-16 US disclosed
EP-0659801-A1 Polyimide MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-06-28 EP disclosed