Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942015 | 0.83 | CYP3A4 (0.66) | EPHX2MAPTL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL1260216 | 0.82 | SMN1; SMN2 (0.62) | EPHX2MAPTL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL11412618 | 0.82 | EPHX2 (0.55) | EPHX2MAPTL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL8371268 | 0.80 | POLB (0.68) | HTTSMN1; SMN2GAAHDAC4HDAC1 | |
| SCHEMBL11250189 | 0.80 | SMN1; SMN2 (0.60) | EPHX2MAPTL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL6372753 | 0.80 | CYP3A4 (0.62) | EPHX2MAPTL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL1689206 | 0.80 | EPHX2 (0.68) | EPHX2MAPTL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL15612337 | 0.79 | CYP1A2 (0.60) | EPHX2MAPTL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL10784058 | 0.79 | EPHX2 (0.52) | EPHX2MAPTL3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL10778946 | 0.79 | EPHX2 (0.52) | EPHX2MAPTL3MBTL1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939387-A | INSULIN LIKE GROWTH HORMONE | ELI LILLY AND COMPANY (US) | 1999-08-17 | — | — | US | claimed |
| EP-0766966-A2 | Method of treating insulin resistance | ELI LILLY AND COMPANY (US) | 1997-04-09 | — | — | EP | claimed |
| WO-1997009060-A1 | METHOD OF TREATING INSULIN RESISTANCE | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | claimed |
| US-5939387-A | INSULIN LIKE GROWTH HORMONE | ELI LILLY AND COMPANY (US) | 1999-08-17 | — | — | US | disclosed |
| EP-0511003-B1 | Superactive GRF analogs | LILLY CO ELI (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0766966-A2 | Method of treating insulin resistance | ELI LILLY AND COMPANY (US) | 1997-04-09 | — | — | EP | disclosed |
| WO-1997009060-A1 | METHOD OF TREATING INSULIN RESISTANCE | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | disclosed |
| CN-1089947-A | New heterogeneous ring compound | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-07-27 | — | — | CN | disclosed |
| EP-0511003-A1 | Superactive GRF analogs | ELI LILLY AND COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| US-4735937-A | ANTIBIOTICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-04-05 | — | — | US | disclosed |
| US-4668781-A | Ceph-3-one compounds and process for their manufacture | CIBA-GEIGY CORPORATION (US) | 1987-05-26 | — | — | US | disclosed |
| US-4269977-A | Process for the manufacture of 8-oxo-5-thia-1-azabicyclo [4,2,0]oct-2-ene or 3-ene compounds | CIBA-GEIGY CORPORATION (US) | 1981-05-26 | — | — | US | disclosed |
| US-4256739-A | 7β-Amino-3-thio-3-cephem-4-carboxylic acid compounds, and antibacterial compositions and methods using them | CIBA-GEIGY CORPORATION (US) | 1981-03-17 | — | — | US | disclosed |
| US-4255328-A | CEPHALOSPORINS | CIBA-GEIGY CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| US-4172832-A | Mercaptoalcohols and process for their manufacture | CIBA-GEIGY CORPORATION (US) | 1979-10-30 | — | — | US | disclosed |
| US-4147864-A | Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds | CIBA-GEIGY CORPORATION (US) | 1979-04-03 | — | — | US | disclosed |
| US-4110533-A | PROCESS FOR THE MANUFACTURE OF ENOL DERIVATIVES | CIBA-GEIGY CORPORATION (US) | 1978-08-29 | — | — | US | disclosed |
| US-4013650-A | PROCESS FOR THE MANUFACTURE OF 3-METHYLENE-CEPHAM COMPOUNDS | CIBA-GEIGY CORPORATION (US) | 1977-03-22 | — | — | US | disclosed |
| US-3989695-A | 7β-Amino-cepham-3-ol-4-carboxylic acid compounds | CIBA-GEIGY CORPORATION (US) | 1976-11-02 | — | — | US | disclosed |
| US-3932465-A | ANTIBIOTIC | CIBA-GEIGY CORPORATION (US) | 1976-01-13 | — | — | US | disclosed |