SCHEMBL8375672

SCHEMBL8375672

CCc1cccc(-c2cc(C#N)ccc2-c2ccccc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 1/20 0.44
LRRK2 Q5S007 1/20 0.43
CYP2A6 P11509 1/20 0.43
CYP19A1 P11511 3/20 0.42
CYP11B1 P15538 2/20 0.42
CYP11B2 P19099 2/20 0.42
CTSS P25774 1/20 0.42
CTSK P43235 1/20 0.42
CYP1A2 P05177 2/20 0.41
CYP2C19 P33261 2/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
TSHR P16473 1/20 0.41
ADRA2C P18825 1/20 0.40
BCL2 P10415 1/20 0.40
ALDH1A1 P00352 2/20 0.40
USP2 O75604 1/20 0.40
MAPK1 P28482 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CLK4 Q9HAZ1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4651880 0.85 TSHR (0.49) PTGDR2CYP19A1CYP11B1CYP11B2CTSS
SCHEMBL8375669 0.85 CYP2A6 (0.55) PTGDR2CYP2A6CYP19A1CYP11B1CYP11B2
SCHEMBL11597170 0.84 TSHR (0.51) PTGDR2CYP19A1CYP11B1CYP11B2TSHR
SCHEMBL3422472 0.82 PTGDR2 (0.53) PTGDR2CYP19A1CYP11B1CYP11B2TSHR
SCHEMBL10929191 0.81 PTGDR2 (0.47) PTGDR2CYP19A1CYP11B2TSHRADRA2C
SCHEMBL8459741 0.81 TP53 (0.52) LRRK2CYP2A6CYP1A2BCL2ALDH1A1
SCHEMBL13266542 0.79 GABRG2 (0.49) LRRK2CYP2A6CTSSCTSKADRA2C
SCHEMBL996126 0.79 PTGDR2 (0.50) PTGDR2CYP19A1CYP11B1CYP11B2TSHR
SCHEMBL20740894 0.79 PTGDR2 (0.50) PTGDR2CYP19A1CYP11B1CYP11B2TSHR
SCHEMBL31741945 0.79 PTGDR2 (0.50) PTGDR2CYP19A1CYP11B1CYP11B2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5958290-A ELECTROOPTICAL APPARATUS WITH DIELECTRIC LIQUID CRYSTALS FOR RADIATION TRANSPARENT MEDIUM MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1999-09-28 US disclosed
US-5344587-A Nitriles MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-09-06 US disclosed