Benzene

Benzene

SCHEMBL8375756

Nc1ccc(S(=O)(=O)O)cc1N.O=P(O)(O)O.c1ccccc1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.56
HSD17B10 Q99714 4/20 0.56
KDM4E B2RXH2 3/20 0.56
GAA P10253 3/20 0.56
PKM P14618 2/20 0.56
MAPT P10636 2/20 0.56
MEN1 O00255 1/20 0.56
RAB9A P51151 1/20 0.56
KMT2A Q03164 1/20 0.56
CASP6 P55212 3/20 0.54
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
TSHR P16473 3/20 0.48
TDP1 Q9NUW8 1/20 0.48
NT5E P21589 3/20 0.47
HTR6 P50406 1/20 0.47
SNCA P37840 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.43
HPGD P15428 1/20 0.43
NSD2 O96028 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL391971 0.88 ALDH1A1 (0.69) ALDH1A1HSD17B10KDM4EGAAPKM
SCHEMBL28975738 0.86 ALDH1A1 (0.67) ALDH1A1HSD17B10KDM4EGAAPKM
Sulfuric Acid SCHEMBL15094054 0.86 GAA (0.73) ALDH1A1HSD17B10KDM4EGAAPKM
Benzene SCHEMBL11045134 0.77 ALDH1A1 (0.60) ALDH1A1HSD17B10KDM4EGAAPKM
SCHEMBL342600 0.76 ALDH1A1 (0.62) ALDH1A1HSD17B10KDM4EGAAPKM
SCHEMBL7692151 0.75 ALDH1A1 (0.65) ALDH1A1HSD17B10KDM4EGAAPKM
SCHEMBL6897205 0.74 ALDH1A1 (0.67) ALDH1A1HSD17B10KDM4EGAAPKM
SCHEMBL745596 0.74 ALDH1A1 (0.73) ALDH1A1HSD17B10KDM4EGAAPKM
SCHEMBL30460505 0.74 ALDH1A1 (0.73) ALDH1A1HSD17B10KDM4EGAAPKM
Phosphoric Acid SCHEMBL230224 0.73 TSHR (0.80) ALDH1A1HSD17B10CYP2C19TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0623159-B1 CONJUGATED POLYMER PAINT FORMULATIONS WHICH PROVIDE CORROSION RESISTANCE TO METAL SURFACES ZIPPERLING KESSLER & CO (DE) 1999-06-16 EP disclosed
EP-0581886-B1 METHOD OF PROCESSING NEUTRAL POLYANILINES IN SOLVENT AND SOLVENT MIXTURES ZIPPERLING KESSLER & CO (DE) 1999-03-10 EP disclosed
US-5853621-A Corrosion resistant paint MONSANTO COMPANY (US) 1998-12-29 US disclosed
EP-0563281-B1 METHOD FOR PROCESSING ELECTRICALLY CONDUCTIVE POLYANILINES IN LEWIS-BASE SOLVENTS MONSANTO CO (US) 1998-08-05 EP disclosed
US-5648416-A NONCONDUCTIVE CONJUGATED POLYMER, POLYANILINES MONSANTO COMPANY (US) 1997-07-15 US disclosed
EP-0623159-A1 CONJUGATED POLYMER PAINT FORMULATIONS WHICH PROVIDE CORROSION RESISTANCE TO METAL SURFACES AlliedSignal Inc. (US) 1994-11-09 EP disclosed
EP-0593648-A1 CONDUCTIVE POLYMER FILM FORMATION USING INITIATOR PRETREATMENT AlliedSignal Inc. (US) 1994-04-27 EP disclosed
EP-0581886-A1 METHOD OF PROCESSING NEUTRAL POLYANILINES IN SOLVENT AND SOLVENT MIXTURES AlliedSignal Inc. (US) 1994-02-09 EP disclosed
EP-0563281-A1 METHOD FOR PROCESSING ELECTRICALLY CONDUCTIVE POLYANILINES IN LEWIS-BASE SOLVENTS AlliedSignal Inc. (US) 1993-10-06 EP disclosed
EP-0563289-A1 METHOD OF PROCESSING ELECTRICALLY CONDUCTIVE POLYANILINES IN SOLVENT MIXTURES AlliedSignal Inc. (US) 1993-10-06 EP disclosed
WO-1993014166-A1 CONJUGATED POLYMER PAINT FORMULATIONS WHICH PROVIDE CORROSION RESISTANCE TO METAL SURFACES ALLIED-SIGNAL INC. (US) 1993-07-22 WO disclosed
WO-1993001229-A1 CONDUCTIVE POLYMER FILM FORMATION USING INITIATOR PRETREATMENT ALLIED-SIGNAL INC. (US) 1993-01-21 WO disclosed
US-5171478-A Doping with organic acids or salts; electroconductive ALLIED-SIGNAL INC. (US) 1992-12-15 US disclosed
WO-1992018572-A2 METHOD OF PROCESSING NEUTRAL POLYANILINES IN SOLVENT AND SOLVENT MIXTURES ALLIED-SIGNAL INC. (US) 1992-10-29 WO disclosed
WO-1992015632-A1 THERMALLY INDUCED CHAIN COUPLING IN SOLID STATE POLYANILINE ALLIED-SIGNAL INC. (US) 1992-09-17 WO disclosed
WO-1992011644-A1 METHOD OF PROCESSING ELECTRICALLY CONDUCTIVE POLYANILINES IN SOLVENT MIXTURES ALLIED-SIGNAL INC. (US) 1992-07-09 WO disclosed
WO-1992011645-A1 METHOD FOR PROCESSING ELECTRICALLY CONDUCTIVE POLYANILINES IN LEWIS-BASE SOLVENTS ALLIED-SIGNAL INC. (US) 1992-07-09 WO disclosed
EP-0461182-A1 THERMALLY STABLE FORMS OF ELECTRICALLY CONDUCTIVE POLYANILINE. ALLIED SIGNAL INC (US) 1991-12-18 EP disclosed
WO-1990010297-A1 THERMALLY STABLE FORMS OF ELECTRICALLY CONDUCTIVE POLYANILINE ALLIED-SIGNAL INC. (US) 1990-09-07 WO disclosed