Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | HTR1B | P28222 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16058112 | 0.82 | CNR1 (0.44) | AOC3CNR1CNR2CYP2C9HTR1B | |
| SCHEMBL25329203 | 0.81 | CASP1 (0.36) | KDM4EKMT2AALDH1A1 | |
| SCHEMBL7931404 | 0.80 | KDM4E (0.44) | AOC3CNR1CNR2CYP2C9HTR1B | |
| SCHEMBL6756012 | 0.77 | NPC1 (0.43) | ALDH1A1 | |
| SCHEMBL8375755 | 0.77 | AOC3 (0.62) | AOC3CYP2C9ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL8377421 | 0.77 | KDM4E (0.42) | CNR1CNR2CYP2C9KDM4EKMT2A | |
| SCHEMBL28188122 | 0.77 | KDM4E (0.42) | CNR1CNR2CYP2C9KDM4EKMT2A | |
| SCHEMBL28188781 | 0.77 | KDM4E (0.42) | CNR1CNR2CYP2C9KDM4EKMT2A | |
| SCHEMBL28188830 | 0.77 | KDM4E (0.42) | CNR1CNR2CYP2C9KDM4EKMT2A | |
| SCHEMBL28188829 | 0.77 | KDM4E (0.42) | CNR1CNR2CYP2C9KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| CN-1216986-A | Isoxazole derivatives | SANKYO CO (JP) | 1999-05-19 | — | — | CN | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |