Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8372846 | 0.86 | KDM4E (0.42) | JAK2KDM4E | |
| SCHEMBL30007625 | 0.84 | PLA2G2A (0.35) | PARP1DHODHPARP2AURKARPS6KB1 | |
| SCHEMBL8371587 | 0.80 | CYP1A2 (0.39) | PARP1KDM4E | |
| SCHEMBL8374844 | 0.80 | PARP1 (0.40) | PARP1AURKARPS6KB1BTKKDM4E | |
| SCHEMBL8373611 | 0.80 | PARP1 (0.40) | PARP1AURKARPS6KB1BTKJAK2 | |
| SCHEMBL8375950 | 0.80 | PARP1 (0.37) | PARP1AURKARPS6KB1JAK2KDM4E | |
| SCHEMBL8374833 | 0.80 | PKN1 (0.42) | PARP1DHODHPARP2PNPIDO1 | |
| SCHEMBL8372849 | 0.79 | BTK (0.45) | PARP1BTKJAK2KDM4E | |
| SCHEMBL8371603 | 0.77 | PARP1 (0.43) | PARP1AURKARPS6KB1 | |
| SCHEMBL8371575 | 0.77 | PARP1 (0.36) | PARP1DHODHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | claimed |