SCHEMBL8376104

SCHEMBL8376104

O=C1CNC(c2ccccc2C(=O)O)=N1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.41
RAB9A P51151 2/20 0.41
ALDH1A1 P00352 5/20 0.41
ALOX15 P16050 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.40
LMNA P02545 2/20 0.40
MYC P01106 1/20 0.40
MAPT P10636 1/20 0.40
POLB P06746 2/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
ALOX12 P18054 1/20 0.39
LIG1 P18858 1/20 0.38
USP2 O75604 1/20 0.38
TSHR P16473 1/20 0.38
HNF4A P41235 1/20 0.38
GAA P10253 1/20 0.37
PTP4A3 O75365 1/20 0.37
NPC1 O15118 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8376034 0.78 KDM4E (0.59) KDM4ERAB9AALDH1A1ALOX15L3MBTL1
SCHEMBL29726703 0.73 ALDH1A1 (0.52) KDM4ERAB9AALDH1A1ALOX15L3MBTL1
SCHEMBL7799064 0.73 ALDH1A1 (0.52) KDM4ERAB9AALDH1A1ALOX15L3MBTL1
SCHEMBL1526540 0.72 NISCH (0.60)
SCHEMBL10649213 0.70 LIG1 (0.44) KDM4ERAB9AALDH1A1ALOX15L3MBTL1
SCHEMBL7488646 0.70 NISCH (0.56) KDM4ERAB9AALDH1A1ALOX15MYC
SCHEMBL36145 0.70 ALDH1A1 (0.72) KDM4EALDH1A1ALOX15L3MBTL1LMNA
SCHEMBL30028907 0.70 ALDH1A1 (0.72) KDM4EALDH1A1ALOX15L3MBTL1LMNA
SCHEMBL7486584 0.69 NISCH (0.50) KDM4ERAB9AALDH1A1L3MBTL1CYP3A4
Hydrochloric Acid SCHEMBL7579852 0.68 ALDH1A1 (0.68) KDM4EALDH1A1ALOX15L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0290257-B1 HERBICIDAL METHOD COMPRISING THE USE OF DIFLUFENICAN MAY & BAKER LIMITED (GB) 1992-04-15 EP claimed
EP-0159287-B1 USE OF QUINOLINE DERIVATIVES TO PROTECT CULTIVATED PLANTS CIBA-GEIGY AG (CH) 1989-10-11 EP claimed
EP-0290257-A2 Herbicidal method comprising the use of diflufenican MAY & BAKER LIMITED (GB) 1988-11-09 EP claimed
EP-0159287-A1 Use of quinoline derivatives to protect cultivated plants CIBA-GEIGY AG (CH) 1985-10-23 EP claimed
EP-0565593-B1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO CO (US) 1999-03-03 EP disclosed
EP-0520371-B1 Isoxazolines and isothiazolines, plant-protecting agent containing them and method of analysis for the identification of potential plant-protecting agents HOECHST SCHERING AGREVO GMBH (DE) 1997-04-09 EP disclosed
US-5484760-A AMIDES MONSANTO COMPANY (US) 1996-01-16 US disclosed
EP-0565593-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1993-10-20 EP disclosed
EP-0520371-A2 Isoxazolines and isothiazolines, plant-protecting agent containing them and method of analysis for the identification of potential plant-protecting agents Hoechst Schering AgrEvo GmbH (DE) 1992-12-30 EP disclosed
WO-1992011761-A1 REDUCING PESTICIDAL INTERACTIONS IN CROPS MONSANTO COMPANY (US) 1992-07-23 WO disclosed
EP-0290257-B1 HERBICIDAL METHOD COMPRISING THE USE OF DIFLUFENICAN MAY & BAKER LIMITED (GB) 1992-04-15 EP disclosed
EP-0159287-B1 USE OF QUINOLINE DERIVATIVES TO PROTECT CULTIVATED PLANTS CIBA-GEIGY AG (CH) 1989-10-11 EP disclosed
US-4851031-A Use of quinoline derivatives for protecting cultivated plants CIBA-GEIGY CORPORATION (US) 1989-07-25 US disclosed
US-4851031-A Use of quinoline derivatives for protecting cultivated plants CIBA-GEIGY CORPORATION (US) 1989-07-25 US disclosed
EP-0290257-A2 Herbicidal method comprising the use of diflufenican MAY & BAKER LIMITED (GB) 1988-11-09 EP disclosed
EP-0290257-A2 Herbicidal method comprising the use of diflufenican MAY & BAKER LIMITED (GB) 1988-11-09 EP disclosed
US-4749406-A Quinoline derivatives and compositions thereof for the protection of cultivated plants CIBA-GEIGY CORPORATION (US) 1988-06-07 US disclosed
EP-0159287-A1 Use of quinoline derivatives to protect cultivated plants CIBA-GEIGY AG (CH) 1985-10-23 EP disclosed
EP-0159287-A1 Use of quinoline derivatives to protect cultivated plants CIBA-GEIGY AG (CH) 1985-10-23 EP disclosed