Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.50 |
| ▸ | BACE1 | P56817 | 4/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 11/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378408 | 0.86 | ACHE (0.70) | ACHEBACE1PDE5AHTR1AKIT | |
| Hydrochloric Acid SCHEMBL8379494 | 0.84 | PDE5A (0.55) | ACHEBACE1PDE5AALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8375179 | 0.83 | PDE5A (0.54) | ACHEBACE1PDE5AKDM4EALDH1A1 | |
| SCHEMBL2920637 | 0.82 | PDE5A (0.52) | ACHEBACE1PDE5AMEN1KMT2A | |
| SCHEMBL8374872 | 0.81 | PDE5A (0.51) | ACHEBACE1PDE5AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8375906 | 0.81 | PDE10A (0.64) | ACHEBACE1PDE5AKITMEN1 | |
| SCHEMBL8374536 | 0.80 | PDE5A (0.50) | ACHEBACE1PDE5AKDM4EALDH1A1 | |
| SCHEMBL8377010 | 0.78 | PDE5A (0.48) | ACHEBACE1PDE5AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8374707 | 0.77 | PDE5A (0.47) | ACHEBACE1PDE5AKDM4EALDH1A1 | |
| SCHEMBL14407966 | 0.76 | MAPT (0.56) | ACHEBACE1PDE5AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990117-A | Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives | CELL PATHWAYS, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5614627-A | Quinazoline compounds | EISAI CO., LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0669324-A1 | QUINAZOLINE COMPOUND | Eisai Co., Ltd. (JP) | 1995-08-30 | — | — | EP | disclosed |