Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.54 |
| ▸ | TK1 | P04183 | 7/20 | 0.46 |
| ▸ | TK2 | O00142 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10446918 | 0.89 | RNASE1 (0.55) | RNASE1TK1TK2 | |
| SCHEMBL9014404 | 0.89 | RNASE1 (0.55) | RNASE1TK1TK2 | |
| SCHEMBL6364200 | 0.88 | RNASE1 (0.59) | RNASE1TK1TK2 | |
| SCHEMBL7917157 | 0.87 | RNASE1 (0.54) | RNASE1TK1TK2 | |
| SCHEMBL5489355 | 0.86 | RNASE1 (0.53) | RNASE1TK1TK2 | |
| SCHEMBL5489351 | 0.86 | RNASE1 (0.53) | RNASE1TK1TK2 | |
| SCHEMBL8591071 | 0.86 | RNASE1 (0.55) | RNASE1TK1TK2 | |
| SCHEMBL5475148 | 0.86 | RNASE1 (0.53) | RNASE1TK1TK2 | |
| SCHEMBL30976656 | 0.86 | RNASE1 (0.53) | RNASE1TK1TK2 | |
| SCHEMBL5475154 | 0.86 | RNASE1 (0.53) | RNASE1TK1TK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965721-A | WITH IMPROVED NUCLEASE RESISTANCE AND IMPROVED CELLULAR UPTAKE; FOR ANTISENSE AGENTS AND REGULATION OF RNA EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 1999-10-12 | — | — | US | disclosed |
| US-5610289-A | Backbone modified oligonucleotide analogues | ISIS PHARMACEUTICALS, INC. (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0586570-A4 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGUES | ISIS PHARMACEUTICALS INC (US) | 1996-01-24 | — | — | EP | disclosed |
| EP-0586570-A1 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGUES | ISIS PHARMACEUTICALS, INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992020822-A1 | BACKBONE MODIFIED OLIGONUCLEOTIDE ANALOGUES | ISIS PHARMACEUTICALS, INC. (US) | 1992-11-26 | — | — | WO | disclosed |