Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10407111 | 0.83 | NR4A1 (0.59) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3624238 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4EGAAKMT2AKEAP1 | |
| SCHEMBL5304396 | 0.80 | KMT2A (0.50) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL7610003 | 0.79 | KDM4E (0.67) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL29875368 | 0.79 | KDM4E (0.67) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL978940 | 0.79 | KDM4E (0.67) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL578683 | 0.79 | KDM4E (0.71) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL29052004 | 0.78 | KDM4E (0.65) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL123193 | 0.77 | ALDH1A1 (0.69) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL29196640 | 0.77 | KDM4E (0.69) | ALDH1A1KDM4EGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |