SCHEMBL8377516

SCHEMBL8377516

CC(C)(C)c1cc(CCC(=O)OCCN2C(C)(C)CCC(OC(=O)CCc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)C2(C)C)cc(C(C)(C)C)c1O

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
GAA P10253 8/20 0.38
PKM P14618 1/20 0.38
HTT P42858 1/20 0.38
MAOB P27338 3/20 0.36
MAOA P21397 2/20 0.36
ACHE P22303 1/20 0.35
ALOX5 P09917 1/20 0.34
ALDH1A1 P00352 3/20 0.33
KDM4E B2RXH2 2/20 0.33
MAPT P10636 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
THRB P10828 1/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8400758 0.84 MAOB (0.32) KMT2AMEN1GAAPKMHTT
SCHEMBL4469766 0.84 GAA (0.43) KMT2AMEN1GAAPKMHTT
SCHEMBL206978 0.83 KMT2A (0.43) KMT2AMEN1GAAPKMHTT
SCHEMBL4391057 0.80 KMT2A (0.40) KMT2AMEN1GAAPKMHTT
SCHEMBL22150256 0.80 GAA (0.43) KMT2AMEN1GAAPKMHTT
SCHEMBL20678186 0.79 GAA (0.40) KMT2AMEN1GAAPKMHTT
SCHEMBL28552666 0.79 KMT2A (0.36) KMT2AMEN1GAAPKMHTT
SCHEMBL2958675 0.79 ALOX5 (0.44) KMT2AMEN1GAAPKMHTT
SCHEMBL9180631 0.79 KMT2A (0.42) KMT2AMEN1GAAPKMHTT
SCHEMBL4183573 0.79 KMT2A (0.42) KMT2AMEN1GAAPKMHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5914361-A IMPART HEAT STABILITY TO ORGANIC MATERIALS, INCLUDING POLYOLEFINS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-06-22 US disclosed
US-5902516-A STABILIZER FOR THERMOPLASTIC POLYOLEFIN OR ENGINEERING RESINS SUMITOMO CHEMICAL CO., LTD (JP) 1999-05-11 US disclosed
US-5874494-A DETERIORATION STABILIZER FOR THERMOPLASTIC RESIN; OXIDATION RESISTANCE, DISCOLORATION INHIBITION, HEAT RESISTANCE, CROSSLINKING INHIBITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-02-23 US disclosed
US-5847187-A Organic phosphorous compound, a process for producing the same and a use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-12-08 US disclosed
US-5830936-A THERMAL STABILIZERS FOR POLYOLEFINS AND ENGINEERING PLASTICS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-11-03 US disclosed