Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378353 | 1.00 | MAOB (0.47) | MAOBNR4A2MRGPRX4PKMTP53 | |
| Amelubant SCHEMBL1891672 | 0.94 | MAOB (0.45) | MAOBNR4A2MRGPRX4PKMTP53 | |
| Amelubant SCHEMBL13696755 | 0.94 | MAOB (0.45) | MAOBNR4A2MRGPRX4PKMTP53 | |
| SCHEMBL15063232 | 0.85 | MAOB (0.39) | MAOBNR4A2MRGPRX4PKMTP53 | |
| SCHEMBL8378347 | 0.83 | F2 (0.51) | MAOBNR4A2MRGPRX4PKMSMN1; SMN2 | |
| SCHEMBL8378348 | 0.83 | F2 (0.51) | MAOBNR4A2MRGPRX4PKMSMN1; SMN2 | |
| SCHEMBL8631529 | 0.82 | NPC1 (0.46) | MAOBNR4A2MRGPRX4PKMTP53 | |
| SCHEMBL8518418 | 0.80 | GPR132 (0.49) | MAOBNR4A2MRGPRX4SMN1; SMN2PTPRC | |
| SCHEMBL8518423 | 0.80 | GPR132 (0.49) | MAOBNR4A2MRGPRX4SMN1; SMN2PTPRC | |
| SCHEMBL8630197 | 0.76 | MRGPRX4 (0.47) | NR4A2MRGPRX4PKMTP53NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770059-B1 | SUBSTITUTED BENZAMIDINES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-07 | — | — | EP | claimed |
| EP-0770059-A1 | SUBSTITUTED BENZAMIDINES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 1997-05-02 | — | — | EP | claimed |
| WO-1996002497-A1 | SUBSTITUTED BENZAMIDINES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 1996-02-01 | — | — | WO | claimed |
| EP-0770059-A1 | SUBSTITUTED BENZAMIDINES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996002497-A1 | SUBSTITUTED BENZAMIDINES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 1996-02-01 | — | — | WO | disclosed |