Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6484578 | 0.86 | FFAR1 (0.66) | KMT2AFFAR1L3MBTL1ATMHPGD | |
| SCHEMBL18039146 | 0.85 | FFAR1 (0.55) | KMT2AFFAR1ATMFNTAFNTB | |
| SCHEMBL18055503 | 0.84 | FNTA (0.59) | KMT2AFFAR1ATMHPGDLMNA | |
| SCHEMBL18228824 | 0.84 | KMT2A (0.58) | KMT2AFFAR1L3MBTL1ATMHPGD | |
| SCHEMBL7925442 | 0.83 | SLC6A2 (0.47) | FFAR1FNTAFNTB | |
| SCHEMBL9444866 | 0.83 | SLC6A2 (0.47) | FFAR1FNTAFNTB | |
| SCHEMBL28489153 | 0.81 | FFAR1 (0.61) | KMT2AFFAR1L3MBTL1ATMHPGD | |
| SCHEMBL21959755 | 0.80 | HTRA1 (0.59) | KMT2AHTRA1HPGDLMNAGAA | |
| SCHEMBL13214514 | 0.80 | FFAR1 (0.43) | KMT2AFFAR1LMNA | |
| SCHEMBL28490573 | 0.78 | FFAR1 (0.79) | KMT2AFFAR1ATMHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531653-B | Novel difluoroketoamide derivatives | 豪夫迈·罗氏有限公司 | 2021-10-19 | — | — | CN | disclosed |
| EP-3294718-B1 | NEW DIFLUOROKETAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-04-29 | — | — | EP | disclosed |
| EP-3294718-B1 | NEW DIFLUOROKETAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-04-29 | — | — | EP | disclosed |
| EP-3262026-B1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-03-18 | — | — | EP | disclosed |
| EP-3262026-B1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-03-18 | — | — | EP | disclosed |
| US-10428108-B2 | Difluoroketamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-10428108-B2 | Difluoroketamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-9980929-B2 | Trifluoromethylpropanamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-9980929-B2 | Trifluoromethylpropanamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-9980929-B2 | Trifluoromethylpropanamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-20180057526-A1 | NEW DIFLUOROKETAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-03-01 | — | — | US | disclosed |
| US-20180057526-A1 | NEW DIFLUOROKETAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2018-03-01 | — | — | US | disclosed |
| CN-107531653-A | Novel difluoroketoamide derivatives | 豪夫迈·罗氏有限公司 | 2018-01-02 | — | — | CN | disclosed |
| US-20170348257-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-12-07 | — | — | US | disclosed |
| US-20170348257-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-12-07 | — | — | US | disclosed |
| US-20170348257-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-12-07 | — | — | US | disclosed |
| WO-2016180751-A1 | NEW DIFLUOROKETAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016180751-A1 | NEW DIFLUOROKETAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016135070-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-01 | — | — | WO | disclosed |
| US-5948807-A | ANTIDOPAMINE, ANTISEROTONIN AGENTS; ALGESICS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1999-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348257-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES | PRMT7, GFRA3, PRMT5 | KMT2A 768/4885FFAR1 293/4885L3MBTL1 2435/4885 |
| US-20180057526-A1 | NEW DIFLUOROKETAMIDE DERIVATIVES | PRMT9, CDK9, FLT3 | KMT2A 283/4885FFAR1 858/4885L3MBTL1 2127/4885 |
| US-10428108-B2 | Difluoroketamide derivatives | PRMT9, CDK9, FLT3 | KMT2A 188/4885FFAR1 964/4885L3MBTL1 2228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.