Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8380927 | 1.00 | ABCB1 (0.54) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8431248 | 0.93 | ABCB1 (0.49) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL5400970 | 0.86 | CHRM1 (0.55) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8473520 | 0.86 | CYP3A4 (0.53) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8473516 | 0.86 | CYP3A4 (0.53) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8332282 | 0.85 | ABCB1 (0.53) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8336752 | 0.83 | ABCB1 (0.53) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL8377313 | 0.82 | GPR119 (0.50) | ABCB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL13150327 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KDM4EL3MBTL1GFERNPC1 | |
| SCHEMBL14593289 | 0.80 | ABCB1 (0.51) | ABCB1CHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304077-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-12-04 | — | — | US | disclosed |
| US-20070179297-A1 | Chemical compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2007-08-02 | — | — | US | disclosed |
| US-7238811-B2 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-03 | — | — | US | disclosed |
| US-7179922-B2 | 4-Phenyloxypiperidionopiperidine compounds as antiinflammatory agents; autoimmune diseases; rheumatic diseases; cardiovascular disorders | ASTRAZENECA AB (SE) | 2007-02-20 | — | — | US | disclosed |
| US-5998416-A | Piperazine, piperidine and tetrahydropyridine derivatives as 5-HT receptor agonists | MERCK SHARP & DOHME LTD. (GB) | 1999-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179297-A1 | Chemical compounds | CCR3, CCR1, CCR4 | ABCB1 622/4885CHRM2 354/4885CHRM4 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.