Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7794834 | 0.99 | MAPT (0.35) | MAPTNPSR1ADRA1DADRA1AADRA1B | |
| SCHEMBL7792045 | 0.83 | CYP1A1 (0.38) | MAPTNPSR1ADRA1DADRA1AADRA1B | |
| Iodide SCHEMBL7792211 | 0.82 | CYP1A1 (0.38) | MAPTNPSR1ADRA1DADRA1AADRA1B | |
| SCHEMBL7794718 | 0.79 | NPSR1 (0.36) | NPSR1ADRA1DADRA1AADRA1BCYP19A1 | |
| Iodide SCHEMBL7794833 | 0.67 | NPSR1 (0.36) | MAPTNPSR1ADRA1DADRA1AADRA1B | |
| SCHEMBL23747291 | 0.66 | NPSR1 (0.48) | MAPTNPSR1ADRA1DADRA1AADRA1B | |
| SCHEMBL4836705 | 0.65 | KMT2A (0.36) | MEN1KMT2ATDP1 | |
| SCHEMBL7792695 | 0.64 | SMN1; SMN2 (0.55) | NPSR1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3632568 | 0.63 | IRAK4 (0.50) | MAPTNPSR1ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL31634047 | 0.63 | IRAK4 (0.50) | MAPTNPSR1ALDH1A1CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |