Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7792184 | 0.83 | KMT2A (0.45) | SMN1; SMN2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27478705 | 0.82 | IRAK4 (0.57) | ALDH1A1KDM4EIRAK4HPGD | |
| SCHEMBL7267474 | 0.81 | SMN1; SMN2 (0.79) | SMN1; SMN2ALDH1A1KDM4EPOLBAKR1C3 | |
| SCHEMBL29853676 | 0.81 | SMN1; SMN2 (0.79) | SMN1; SMN2ALDH1A1KDM4EPOLBAKR1C3 | |
| SCHEMBL14397805 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1KDM4EPOLBAKR1C3 | |
| SCHEMBL6536172 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1KDM4EPOLBAKR1C3 | |
| SCHEMBL1282546 | 0.78 | ALDH1A1 (0.62) | SMN1; SMN2ALDH1A1KDM4EPOLBAKR1C3 | |
| SCHEMBL5096410 | 0.78 | PTGER1 (0.62) | SMN1; SMN2KDM4EPOLBNPSR1RAB9A | |
| SCHEMBL7786417 | 0.78 | POLB (0.48) | SMN1; SMN2ALDH1A1KDM4EPOLBAKR1C3 | |
| SCHEMBL28036196 | 0.77 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1KDM4EPOLBAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906268-B1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | AVENTIS PHARMA INC (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6004959-A | HYPOTENSIVE, ANTITUMOR, ANTIINFLAMMATORY AND ANTIASTHMATIC AGENTS; ANGIOGENESIS AND ALVEOLAR MACROPHAGE ACTIVATION INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |