Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.55 |
| ▸ | BCL9 | O00512 | 1/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127812 | 0.92 | BCL9 (0.60) | BCL9CTNNB1KMT2ASMN1; SMN2ESR1 | |
| SCHEMBL28868840 | 0.85 | ELANE (0.76) | ELANEBCL9CTNNB1KMT2AESR1 | |
| SCHEMBL11105468 | 0.85 | KMT2A (0.48) | BCL9CTNNB1KMT2ASMN1; SMN2ESR1 | |
| SCHEMBL11108556 | 0.85 | KMT2A (0.48) | BCL9CTNNB1KMT2ASMN1; SMN2ESR1 | |
| SCHEMBL11023644 | 0.82 | BCL9 (0.70) | ELANEBCL9CTNNB1KMT2ASMN1; SMN2 | |
| SCHEMBL4312695 | 0.81 | HTR7 (0.56) | BCL9CTNNB1KMT2ASMN1; SMN2HTR7 | |
| SCHEMBL29279079 | 0.80 | KMT2A (0.63) | BCL9CTNNB1KMT2ASMN1; SMN2ESR1 | |
| SCHEMBL27567778 | 0.80 | KMT2A (0.57) | BCL9CTNNB1KMT2ASMN1; SMN2HTR7 | |
| SCHEMBL6562062 | 0.80 | BCL9 (0.58) | ELANEBCL9CTNNB1KMT2ASMN1; SMN2 | |
| SCHEMBL11375092 | 0.80 | KMT2A (0.64) | ELANEBCL9CTNNB1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877296-A | REACTING DISULFIDE ANALOGS OF CALICHEAMICIN FAMILY WITH A CARRIER SUCH AS PROTEIN, PEPTIDE, MONO AND POLYCLONAL ANTIBODIES, THEIR ANTIGEN-RECOGNIZING FRAGMENTS AND CHEMICALLY OR GENETICALLY ENGINEERED COUNTERPARTS | AMERICAN CYANAMID COMPANY (US) | 1999-03-02 | — | — | US | disclosed |
| US-5773001-A | ANTIGROWTH AGENTS | AMERICAN CYANAMID COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
| US-5767285-A | USEFUL FOR CONSTRUCTING DRUG CONJUGATES; ANTIBIOTIC ANTITUMOR AGENTS | AMERICAN CYANAMID COMPANY (US) | 1998-06-16 | — | — | US | disclosed |
| US-5739116-A | DISULFIDE DERIVATIVE OF CALICHEAMICIN FAMILY; ANTITUMOR ANTIBIOTICS | AMERICAN CYANAMID COMPANY (US) | 1998-04-14 | — | — | US | disclosed |