Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.39 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL839577 | 0.85 | ALDH1A1 (0.39) | LMNATP53SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL4928544 | 0.78 | ALDH1A1 (0.56) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| SCHEMBL839657 | 0.73 | SLC2A1 (0.54) | LMNATP53SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9476934 | 0.73 | ALDH1A1 (0.53) | LMNATP53SMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL2732314 | 0.72 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| SCHEMBL21138500 | 0.72 | POLB (0.39) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| SCHEMBL4928331 | 0.69 | TP53 (0.49) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| SCHEMBL1244897 | 0.68 | GPR119 (0.48) | LMNASMN1; SMN2ALDH1A1HPGDMAPT | |
| SCHEMBL4922738 | 0.67 | ALDH1A1 (0.64) | LMNAALDH1A1TSHRHTTHPGD | |
| SCHEMBL21138789 | 0.67 | ALDH1A1 (0.40) | LMNAALDH1A1SLC2A1SLC2A2SLC2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-04-15 | — | — | US | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093757-A1 | THERAPEUTIC AGENTS 414 | GCK, GCKR, GPR119 | PI4KA 486/4885PI4K2B 578/4885PI4K2A 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.