Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.56 |
| ▸ | CDC25B | P30305 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28740658 | 0.84 | NR4A1 (0.50) | NR4A1NR4A2NR4A3CDC25BPTPN1 | |
| SCHEMBL25384255 | 0.84 | CDC25B (0.51) | NR4A1NR4A2NR4A3CDC25BPTPN1 | |
| SCHEMBL30546550 | 0.84 | CDC25B (0.51) | NR4A1NR4A2NR4A3CDC25BPTPN1 | |
| SCHEMBL15658687 | 0.81 | NR4A1 (0.53) | NR4A1NR4A2NR4A3CDC25BPTPN1 | |
| SCHEMBL4114028 | 0.79 | PTPN1 (0.54) | NR4A1NR4A2NR4A3CDC25BPTPN1 | |
| SCHEMBL1878466 | 0.79 | SLC6A2 (0.48) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL25384484 | 0.77 | CDC25B (0.42) | NR4A1NR4A2NR4A3CDC25BPLK1 | |
| SCHEMBL4326257 | 0.77 | CES2 (0.50) | PTPN1MEN1KMT2ATDP1KDM4E | |
| SCHEMBL2292145 | 0.77 | ALDH1A1 (0.52) | ALDH1A1POLBHPGDTP53TSHR | |
| SCHEMBL27960653 | 0.77 | CES2 (0.50) | PTPN1MEN1KMT2ATDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958934-A | 5-HT 2B ANTAGONIST | SYNTEX (U.S.A.) INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5952331-A | SELECTIVE 5HT2B ANTAGONISTS; SEROTONIN RECEPTOR ANTAGONIST; TREATING DISORDERS OF THE GASTROINTESTINAL TRACK, RESTENOSIS, ASTHMA AND OBSTRUCTIVE AIRWAY DISEASE, PROSTATIC HYPERPLASIA, GENERALIZED ANXIETY, PANIC DISORDER | SYNTEX (USA) INC. (US) | 1999-09-14 | — | — | US | disclosed |