Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGAV | P06756 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8650770 | 1.00 | TP53 (0.58) | TP53HTTGAAMAPTNPSR1 | |
| SCHEMBL14135841 | 0.87 | MAPT (0.60) | TP53HTTGAAMAPTNPSR1 | |
| SCHEMBL5098994 | 0.79 | NTSR1 (0.58) | TP53HTTGAAMAPTNPSR1 | |
| SCHEMBL5099014 | 0.79 | NTSR1 (0.58) | TP53HTTGAAMAPTNPSR1 | |
| Phenanthroline SCHEMBL27819826 | 0.79 | MAPT (0.54) | HTTGAAMAPTNPSR1ITGB3 | |
| SCHEMBL3927035 | 0.79 | BACE1 (0.54) | TP53GAAMAPTNPSR1ITGB3 | |
| SCHEMBL7217344 | 0.78 | MAPT (0.53) | GAAMAPTNPSR1ITGB3ITGAV | |
| SCHEMBL8539708 | 0.78 | GAA (0.52) | HTTGAAMAPTNPSR1ITGB3 | |
| Hydrochloric Acid SCHEMBL7657489 | 0.78 | GAA (0.52) | HTTGAAMAPTNPSR1ITGB3 | |
| SCHEMBL27995018 | 0.78 | GAA (0.52) | HTTGAAMAPTNPSR1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614911-B1 | Compounds having a sulfonamide and an amidinegroup, process for preparation and pharmaceutical compositions comprising them | SANOFI SA (FR) | 1999-04-28 | — | — | EP | disclosed |
| US-5714497-A | EXHIBIT AFFINITY FOR BIOLOGICAL RECEPTORS OF NEUROPEPTIDE Y | SANOFI (FR) | 1998-02-03 | — | — | US | disclosed |
| US-5674890-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS; PSYCHOLOGICAL DISORDERS; ANTAGONISTS OF PEPTIDE Y | SANOFI (FR) | 1997-10-07 | — | — | US | disclosed |
| US-5506258-A | EXHIBIT AFFINITY FOR THE BIOLOGICAL RECEPTORS OF NEUROPEPTIDES Y, WHICH ARE PRESENT IN THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS | ELF SANOFI (FR) | 1996-04-09 | — | — | US | disclosed |
| EP-0614911-A1 | Compounds having a sulfonamide and an amidinegroup, process for preparation and pharmaceutical compositions comprising them | SANOFI (FR) | 1994-09-14 | — | — | EP | disclosed |