Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGAV | P06756 | 1/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7161574 | 0.92 | NPSR1 (0.48) | MAPTNPSR1GAAITGB3ITGAV | |
| SCHEMBL232948 | 0.91 | ITGB3 (0.45) | MAPTNPSR1GAAITGB3ITGAV | |
| Alanine SCHEMBL601223 | 0.89 | ITGB3 (0.44) | MAPTNPSR1GAAITGB3ITGAV | |
| SCHEMBL5098994 | 0.82 | NTSR1 (0.58) | MAPTNPSR1GAAITGB3ITGAV | |
| SCHEMBL5099014 | 0.82 | NTSR1 (0.58) | MAPTNPSR1GAAITGB3ITGAV | |
| Leucine SCHEMBL3814957 | 0.82 | ITGB3 (0.45) | MAPTNPSR1GAAITGB3ITGAV | |
| Leucine SCHEMBL1414045 | 0.80 | ITGB3 (0.47) | MAPTNPSR1GAAITGB3ITGAV | |
| SCHEMBL8385403 | 0.78 | TP53 (0.58) | MAPTNPSR1GAAITGB3ITGAV | |
| SCHEMBL8650770 | 0.78 | TP53 (0.58) | MAPTNPSR1GAAITGB3ITGAV | |
| Phenanthroline SCHEMBL27819826 | 0.78 | MAPT (0.54) | MAPTNPSR1GAAITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617317-B1 | Reducing the rate of degradation of proteins in an animal | MILLENNIUM PHARMACEUTICALS, INC. | 2003-09-09 | — | — | US | claimed |
| US-6465433-B1 | SUCH AS N-(2-PYRIDINE)CARBONYL-L-PHENYLALANINE-L-LEUCINE BORONIC ACID; PROTEASOME INHIBITORS; REDUCING RATE OF MUSCLE PROTEIN DEGRADATION | MILLENNIUM PHARMACEUTICALS, INC. | 2002-10-15 | — | — | US | claimed |
| US-6083903-A | REDUCE RATE OF DEGRADATION OF PROTEINS IN ANIMAL | LEUKOSITE, INC. (US) | 2000-07-04 | — | — | US | claimed |