Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18121825 | 0.78 | NOTUM (0.70) | NOTUMKMT2AKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL23451693 | 0.78 | NOTUM (1.00) | NOTUMKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL14007387 | 0.78 | NOTUM (0.69) | NOTUMKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL1261092 | 0.74 | KIF11 (0.47) | NOTUMKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL5535013 | 0.73 | NOTUM (0.40) | NOTUMKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL10437800 | 0.72 | NOTUM (0.42) | NOTUMKMT2ANPC1IKBKBGPR55 | |
| SCHEMBL15205456 | 0.71 | NOTUM (0.59) | NOTUMKMT2A | |
| SCHEMBL1261067 | 0.70 | PTGS1 (0.48) | NOTUMKMT2ANPC1RAB9ANPSR1 | |
| SCHEMBL16649811 | 0.70 | NOTUM (0.47) | NOTUMKMT2AHPGDALDH1A1 | |
| SCHEMBL18528795 | 0.69 | NPC1 (0.69) | NOTUMKMT2AKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869509-A | TREAT DISORDERS RESPONSIVE TO OPENERS OF THE LARGE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-02-09 | — | — | US | claimed |