SCHEMBL8385652

SCHEMBL8385652

COc1ccc([Si](C)(C)CCOc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 3/20 0.51
CA1 P00915 2/20 0.51
ALOX5 P09917 1/20 0.38
ALDH1A1 P00352 3/20 0.36
GAA P10253 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
PTGS1 P23219 2/20 0.35
PTGS2 P35354 2/20 0.35
MTNR1A P48039 1/20 0.35
MTNR1B P49286 1/20 0.35
HPN P05981 1/20 0.34
MAPT P10636 1/20 0.34
ALOX15 P16050 1/20 0.34
SIRT5 Q9NXA8 1/20 0.34
TNFRSF1A P19438 1/20 0.34
HSP90AA1 P07900 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8038870 0.86 CA2 (0.54) CA2CA1ALOX5ALDH1A1GAA
SCHEMBL7516141 0.81 CA2 (0.54) CA2CA1ALOX5ALDH1A1GAA
SCHEMBL6054892 0.77 CA1 (0.39) CA2CA1PTGS1
SCHEMBL6054913 0.75 CA2 (0.43) CA2CA1ALOX5ALDH1A1GAA
SCHEMBL6054922 0.75 CA2 (0.45) CA2CA1ALDH1A1GAAMEN1
SCHEMBL7520581 0.75 ALDH1A1 (0.49) CA2CA1ALDH1A1GAACYP3A4
SCHEMBL7526574 0.75 CA1 (0.53) CA2CA1ALOX5ALDH1A1GAA
SCHEMBL2879172 0.75 CA2 (0.56) CA2CA1ALDH1A1GAAMEN1
SCHEMBL8959175 0.74 CA2 (0.63) CA2CA1ALDH1A1GAAMEN1
SCHEMBL8385616 0.74 CA2 (0.44) CA2CA1ALDH1A1GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0910384-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1999-04-28 EP claimed
WO-1997040837-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1997-11-06 WO claimed
EP-0910384-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1999-04-28 EP disclosed
WO-1997040837-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1997-11-06 WO disclosed