Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 18/20 | 0.45 |
| ▸ | HTR1B | P28222 | 16/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR1F | P30939 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8383710 | 0.92 | HTR1D (0.45) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8381711 | 0.91 | SLC6A4 (0.45) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8387074 | 0.85 | HTR1D (0.46) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8713578 | 0.85 | SLC6A4 (0.52) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8387309 | 0.84 | HTR1D (0.50) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8720715 | 0.84 | HTR1D (0.43) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL7489434 | 0.84 | HTR1D (0.53) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8383502 | 0.83 | HTR1D (0.47) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8383571 | 0.83 | HTR1D (0.54) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8387496 | 0.83 | MAPK1 (0.48) | HTR1DHTR1BHTR1AHTR1FSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874427-A | MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0875513-A1 | Substituted heteroaromatic 5-HT 1F agonists | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |