Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 12/20 | 0.50 |
| ▸ | HTR1B | P28222 | 11/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR1F | P30939 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708176 | 0.89 | HTR1D (0.53) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8385338 | 0.87 | HTR1D (0.47) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8713578 | 0.86 | SLC6A4 (0.52) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8385368 | 0.86 | HTR1D (0.56) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8383522 | 0.85 | HTR1D (0.48) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8387074 | 0.85 | HTR1D (0.46) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8383502 | 0.85 | HTR1D (0.47) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8383600 | 0.85 | HTR1D (0.48) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8387496 | 0.85 | MAPK1 (0.48) | HTR1DHTR1BHTR1AHTR1FSLC6A4 | |
| SCHEMBL8387183 | 0.84 | HTR1D (0.45) | HTR1DHTR1BHTR1AHTR1FSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874427-A | MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0875513-A1 | Substituted heteroaromatic 5-HT 1F agonists | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |