Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 16/20 | 0.49 |
| ▸ | HTR1B | P28222 | 13/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR1F | P30939 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | NMT2 | O60551 | 1/20 | 0.43 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8383229 | 0.88 | SLC6A4 (0.56) | SLC6A4HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL7482982 | 0.85 | HTR1D (0.68) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8387149 | 0.84 | SLC6A4 (0.58) | SLC6A4HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8386450 | 0.84 | HTR1D (0.49) | SLC6A4HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8383522 | 0.83 | HTR1D (0.48) | SLC6A4HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8708176 | 0.83 | HTR1D (0.53) | SLC6A4HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8385370 | 0.83 | SLC6A4 (0.55) | SLC6A4HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8385368 | 0.82 | HTR1D (0.56) | SLC6A4HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8387309 | 0.82 | HTR1D (0.50) | SLC6A4HTR1DHTR1BHTR1AHTR1F | |
| SCHEMBL8386435 | 0.81 | HTR1D (0.47) | SLC6A4HTR1DHTR1BHTR1AHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874427-A | MIGRAINE | ELI LILLY AND COMPANY (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0875513-A1 | Substituted heteroaromatic 5-HT 1F agonists | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |