Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.47 |
| ▸ | MPL | P40238 | 2/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.45 |
| ▸ | GABRD | O14764 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31124833 | 1.00 | KIF11 (0.50) | KIF11MAPTMAPK1NPSR1PIM3 | |
| SCHEMBL8389062 | 0.87 | MPL (0.56) | KIF11MAPTMAPK1NPSR1PIM3 | |
| SCHEMBL2333357 | 0.84 | PIM3 (0.49) | KIF11MAPTMAPK1NPSR1PIM3 | |
| SCHEMBL30583772 | 0.84 | PIM3 (0.49) | KIF11MAPTMAPK1NPSR1PIM3 | |
| SCHEMBL159997 | 0.81 | PBRM1 (0.57) | KIF11MAPTMAPK1NPSR1PIM3 | |
| SCHEMBL8387303 | 0.81 | KDM4E (0.59) | MAPTMAPK1NPSR1GABRPGABRD | |
| Acetic Acid SCHEMBL11537832 | 0.79 | MPL (0.51) | KIF11MAPTMAPK1NPSR1PIM3 | |
| SCHEMBL9056003 | 0.77 | SLC22A6 (0.51) | KIF11MAPTMAPK1NPSR1PIM3 | |
| SCHEMBL5964419 | 0.76 | KIF11 (0.56) | KIF11MAPTMAPK1NPSR1PARP14 | |
| SCHEMBL29726990 | 0.75 | KIF11 (0.66) | KIF11MAPTMAPK1NPSR1GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877199-A | ALZHEIMER'S DISEASE; SEDATIVE | SANKYO COMPANY, LIMITED (JP) | 1999-03-02 | — | — | US | disclosed |
| CN-1166169-A | Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors | SANKYO CO (JP) | 1997-11-26 | — | — | CN | disclosed |
| EP-0804416-A1 | HETEROCYCLIC COMPOUNDS, USEFUL AS ALLOSTERIC EFFECTORS AT MUSCARINIC RECEPTORS | SANKYO COMPANY LIMITED (JP) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996003377-A1 | HETEROCYCLIC COMPOUNDS, USEFUL AS ALLOSTERIC EFFECTORS AT MUSCARINIC RECEPTORS | SANKYO COMPANY, LIMITED (JP) | 1996-02-08 | — | — | WO | disclosed |