Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8386061 | 0.92 | CTSS (0.37) | RXRARXRBNLRP3ALOX5APFEN1 | |
| SCHEMBL8651015 | 0.80 | ABL1 (0.35) | PTGS1ALOX5APFEN1HTTALDH1A1 | |
| SCHEMBL8387382 | 0.75 | AKR1C3 (0.36) | NLRP3ALOX5APFEN1HTTCTSS | |
| SCHEMBL23915997 | 0.74 | ALOX5AP (0.44) | RXRARXRBRXRGALOX5APFEN1 | |
| SCHEMBL8387020 | 0.73 | KDM4E (0.42) | HTTLMNAPOLBHIF1AALDH1A1 | |
| SCHEMBL8388339 | 0.72 | IKBKB (0.42) | HTTCTSSCTSKLMNAPOLB | |
| SCHEMBL8390382 | 0.72 | ADORA2A (0.44) | HTTSMN1; SMN2ALDH1A1MAPTPKM | |
| SCHEMBL8649829 | 0.70 | IKBKB (0.40) | ALOX5APFEN1HTTCTSSCTSK | |
| SCHEMBL8390378 | 0.69 | MAOB (0.32) | — | |
| SCHEMBL8385922 | 0.68 | DHFR (0.39) | PTGS1ALDH1A1MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874579-A | Insecticidal substituted-2.4-diaminoquinazolines related applications | FMC CORPORATION (US) | 1999-02-23 | — | — | US | disclosed |
| US-5616718-A | USEFUL FOR MAKING 2,4-DIAMINOQUINAZOLINES; INSECTICIDES | FMC CORPORATION (US) | 1997-04-01 | — | — | US | disclosed |
| US-5534518-A | Insecticidal substituted-2,4-diaminoquinazolines | FMC CORPORATION (US) | 1996-07-09 | — | — | US | disclosed |
| EP-0684824-A4 | INSECTICIDAL SUBSTITUTED-2,4-DIAMINOQUINAZOLINES. | FMC CORP (US) | 1996-02-14 | — | — | EP | disclosed |
| EP-0684824-A1 | INSECTICIDAL SUBSTITUTED-2,4-DIAMINOQUINAZOLINES | FMC CORPORATION (US) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994018980-A1 | INSECTICIDAL SUBSTITUTED-2,4-DIAMINOQUINAZOLINES | FMC CORPORATION (US) | 1994-09-01 | — | — | WO | disclosed |