Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL5665509 | 0.81 | TET2 (0.40) | TET2TSHRALDH1A1HMGCRCHRM1 | |
| SCHEMBL4961008 | 0.80 | CYP2C9 (0.39) | TSHRALDH1A1CYP2D6CYP2C19HIF1A | |
| SCHEMBL3142027 | 0.79 | ALDH1A1 (0.38) | TET2TSHRALDH1A1HMGCRCHRM1 | |
| Ammonia Solution, Strong SCHEMBL11068438 | 0.78 | CYP2C9 (0.38) | TSHRALDH1A1CYP2D6CYP2C19HIF1A | |
| SCHEMBL14448144 | 0.78 | TSHR (0.44) | TSHRALDH1A1CYP2D6CYP2C19HIF1A | |
| SCHEMBL17580945 | 0.78 | ALDH1A1 (0.35) | TSHRALDH1A1 | |
| SCHEMBL5524511 | 0.75 | — | — | |
| SCHEMBL5050665 | 0.74 | TSHR (0.41) | TSHRALDH1A1CYP2D6CYP2C19HIF1A | |
| SCHEMBL25660735 | 0.74 | GGT1 (0.42) | TSHRALDH1A1ADRA1ACYP2D6CYP2C19 | |
| Pivalate SCHEMBL11039116 | 0.74 | ALDH1A1 (0.40) | TSHRALDH1A1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143263-B2 | Therapeutic agents | ASTRAZENECA AB (SE) | 2012-03-27 | — | — | US | disclosed |
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |