Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | SLC22A12 | Q96S37 | 5/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4506807 | 0.82 | PPARG (0.61) | ALDH1A1HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL8386934 | 0.82 | KDM4E (0.65) | ALDH1A1KDM4EHPGDHSD17B10HDAC3 | |
| SCHEMBL8386913 | 0.81 | HDAC3 (0.56) | ALDH1A1HDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL9056975 | 0.78 | PLA2G2A (0.56) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL7963412 | 0.77 | PLA2G2A (0.65) | ALDH1A1PLA2G2APLA2G1BPTGDR2 | |
| SCHEMBL12398081 | 0.77 | TDP1 (0.63) | ALDH1A1KDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL2002870 | 0.76 | PLA2G2A (0.82) | ALDH1A1KDM4EPLA2G2APLA2G1BPTGDR2 | |
| SCHEMBL11289374 | 0.76 | CYP19A1 (0.66) | ALDH1A1KDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL8391190 | 0.76 | KDM4E (0.60) | ALDH1A1KDM4EHPGDHSD17B10HDAC3 | |
| SCHEMBL8602152 | 0.76 | SLC22A12 (0.78) | ALDH1A1KDM4EHPGDHSD17B10HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877199-A | ALZHEIMER'S DISEASE; SEDATIVE | SANKYO COMPANY, LIMITED (JP) | 1999-03-02 | — | — | US | disclosed |
| EP-0804416-A1 | HETEROCYCLIC COMPOUNDS, USEFUL AS ALLOSTERIC EFFECTORS AT MUSCARINIC RECEPTORS | SANKYO COMPANY LIMITED (JP) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996003377-A1 | HETEROCYCLIC COMPOUNDS, USEFUL AS ALLOSTERIC EFFECTORS AT MUSCARINIC RECEPTORS | SANKYO COMPANY, LIMITED (JP) | 1996-02-08 | — | — | WO | disclosed |