Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8385558 | 0.82 | ASIC3 (0.61) | ASIC3GRM5PIK3CDNTRK1PIK3C3 | |
| SCHEMBL16195746 | 0.81 | GRM5 (0.46) | ASIC3GRM5PIK3CDMAOAMAOB | |
| SCHEMBL12843909 | 0.80 | ASIC3 (0.53) | ASIC3GRM5PIK3CDPIK3C3CYP3A4 | |
| SCHEMBL8386135 | 0.79 | ASIC3 (0.52) | ASIC3GRM5PIK3CDMAOAPIK3C3 | |
| SCHEMBL13598169 | 0.78 | MAOB (0.58) | GSTP1MAOAMAOBHRH3 | |
| SCHEMBL3875255 | 0.77 | MAOA (0.68) | MAOAMAOBHRH3ALOX5 | |
| Hydrochloric Acid SCHEMBL3902877 | 0.76 | MAOB (0.56) | GSTP1MAOAMAOBHRH3 | |
| Hydrochloric Acid SCHEMBL3902331 | 0.76 | MAOA (0.66) | MAOAMAOBHRH3ALOX5 | |
| SCHEMBL4717674 | 0.76 | MAOB (0.66) | MAOAMAOBHRH3ALOX5 | |
| SCHEMBL10293323 | 0.74 | ASIC3 (0.62) | ASIC3GRM5PIK3CDNTRK1PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | PLEXXIKON INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | MAP4K1, MAP4K2, MAP3K1 | ASIC3 4092/4885GRM5 3903/4885PIK3CD 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.