Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 8/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 3/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466879 | 0.88 | EDNRB (0.48) | CCR2ABCB11LTB4RLTB4R2SRD5A2 | |
| SCHEMBL8389272 | 0.87 | CCR2 (0.54) | CCR2ABCB11LTB4RLTB4R2SRD5A2 | |
| SCHEMBL7466632 | 0.86 | CCR2 (0.45) | CCR2ABCB11LTB4RLTB4R2SRD5A2 | |
| SCHEMBL7465994 | 0.84 | PLA2G4A (0.46) | CCR2ABCB11LTB4RLTB4R2SRD5A2 | |
| SCHEMBL7467118 | 0.83 | CCR2 (0.50) | CCR2ABCB11LTB4RLTB4R2SRD5A2 | |
| SCHEMBL7137416 | 0.83 | CCR2 (0.45) | CCR2ABCB11LTB4RLTB4R2SRD5A2 | |
| SCHEMBL7473359 | 0.82 | CCR2 (0.44) | CCR2ABCB11PLA2G4AMCL1 | |
| SCHEMBL7470926 | 0.82 | CCR2 (0.44) | CCR2ABCB11PLA2G4AMCL1 | |
| SCHEMBL7468637 | 0.80 | CCR2 (0.47) | CCR2ABCB11LTB4RLTB4R2SRD5A2 | |
| SCHEMBL8617227 | 0.76 | SRD5A2 (0.46) | LTB4RLTB4R2SRD5A2EDNRBMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955492-A | Carboxylic acid indole inhibitors of chemokines | SMITHKLINE BEECHAM CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |