Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27877627 | 0.86 | PDE2A (0.47) | PDE2AHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL31704883 | 0.85 | PDE2A (0.46) | PDE2AHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL31706720 | 0.85 | PDE2A (0.46) | PDE2AHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL27850851 | 0.85 | PDE2A (0.64) | PDE2AHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL2481758 | 0.85 | PDE2A (0.64) | PDE2AHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL22747383 | 0.84 | PDE2A (0.44) | PDE2AHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL12889906 | 0.81 | PDE2A (0.53) | PDE2AHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL25358453 | 0.79 | PDE2A (0.41) | PDE2APTPN5KIF11NPSR1 | |
| SCHEMBL10304787 | 0.79 | PDE2A (0.52) | PDE2AHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL8291096 | 0.78 | PDE2A (0.50) | PDE2AHTR2AHTR2CHTR2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149557-A1 | CXCR3 antagonists | AMGEN INC. (US) | 2007-06-28 | — | — | US | disclosed |
| US-5877191-A | ANTIINFLAMMATORY AGENT; ANALGESICS; ANTIHISTAMINES; EMESIS | MERCK & CO., INC. (US) | 1999-03-02 | — | — | US | disclosed |
| WO-1998017660-A1 | PHENYL SPIROETHERCYCLOALKYL TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149557-A1 | CXCR3 antagonists | CXCR3, CXCR1, CCR5 | PDE2A 2737/4885HTR2A 2430/4885HTR2C 2864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.