Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3854785 | 0.77 | KMT2A (0.56) | ALDH1A1GAAKMT2AMEN1RCE1 | |
| SCHEMBL6935702 | 0.75 | KMT2A (0.53) | ALDH1A1GAAKMT2AMEN1RCE1 | |
| Bromide SCHEMBL4189993 | 0.69 | — | — | |
| SCHEMBL347422 | 0.68 | — | — | |
| Hydrogen Sulfide SCHEMBL28240009 | 0.66 | — | — | |
| SCHEMBL28252394 | 0.64 | KDM4E (0.36) | ALDH1A1KMT2AMEN1 | |
| Bromide SCHEMBL9637361 | 0.60 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL25562762 | 0.58 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL14008412 | 0.58 | ALDH1A1 (0.55) | ALDH1A1 | |
| SCHEMBL6938305 | 0.57 | ALDH1A1 (0.55) | ALDH1A1GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6007865-A | FOR INHIBITING AND REVERSING NONENZYMATIC CROSS-LINKING (PROTEIN AGING), TREATING KIDNEY DAMAGE AND TREATING COMPLICATIONS OF DIABETES, PREVENTING FOOD SPOILAGE | ALTEON INC. | 1999-12-28 | — | — | US | disclosed |