Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 3/20 | 0.53 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8394017 | 0.90 | LMNA (0.58) | KMT2ANAMPTEPHX2LMNANPC1 | |
| SCHEMBL8392950 | 0.90 | KDM1A (0.53) | MCHR1NAMPTLMNANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8397090 | 0.89 | LMNA (0.57) | KMT2ANAMPTEPHX2LMNANPC1 | |
| Hydrochloric Acid SCHEMBL8392052 | 0.89 | KDM1A (0.52) | MCHR1LMNANPC1RAB9APARP1 | |
| SCHEMBL8394079 | 0.84 | NPC1 (0.54) | KMT2ANAMPTEPHX2LMNANPC1 | |
| SCHEMBL8392756 | 0.83 | KMT2A (0.53) | KMT2ANAMPTEPHX2LMNANPC1 | |
| Hydrochloric Acid SCHEMBL8395526 | 0.83 | NPC1 (0.53) | KMT2ANAMPTEPHX2LMNANPC1 | |
| Hydrochloric Acid SCHEMBL8394145 | 0.82 | KMT2A (0.53) | KMT2ANAMPTEPHX2LMNANPC1 | |
| SCHEMBL8395852 | 0.79 | MAPK1 (0.55) | KMT2ALMNANPC1RAB9A | |
| SCHEMBL8525511 | 0.78 | NAMPT (0.57) | MCHR1NAMPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690851-B1 | GUANIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AB (SE) | 1999-05-19 | — | — | EP | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | disclosed |