Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 8/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GALR1 | P47211 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524910 | 0.93 | NAMPT (0.64) | NAMPTNPC1RAB9A | |
| SCHEMBL8523428 | 0.92 | NAMPT (0.60) | NAMPTNPC1RAB9A | |
| SCHEMBL8395266 | 0.88 | ALDH1A1 (0.59) | NAMPTNPC1RAB9AMCHR1CYP2D6 | |
| SCHEMBL8396226 | 0.88 | ALDH1A1 (0.56) | NAMPTHDAC2HDAC8HDAC6RAB9A | |
| SCHEMBL8394017 | 0.87 | LMNA (0.58) | NAMPTHDAC2HDAC8HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL8397090 | 0.86 | LMNA (0.57) | NAMPTHDAC2HDAC8HDAC6HDAC1 | |
| SCHEMBL8524903 | 0.85 | NAMPT (0.67) | NAMPTMCHR1CYP2D6CHRM1HTR2A | |
| SCHEMBL8394079 | 0.81 | NPC1 (0.54) | NAMPTNPC1RAB9A | |
| SCHEMBL8392136 | 0.81 | GAA (0.46) | NAMPTNPC1RAB9AGAA | |
| Hydrochloric Acid SCHEMBL8395526 | 0.80 | NPC1 (0.53) | NAMPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | claimed |
| US-5885985-A | Guanidine derivatives useful in therapy | ASTRA AKTIEBOLAG (SE) | 1999-03-23 | — | — | US | disclosed |