Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.60 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.60 |
| ▸ | AGT | P01019 | 2/20 | 0.58 |
| ▸ | PPARG | P37231 | 8/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8789152 | 0.90 | AGT (0.58) | AGTR1AGTR2AGT | |
| SCHEMBL9168768 | 0.90 | AGTR1 (0.57) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL9854421 | 0.88 | AGTR1 (0.62) | AGTR1AGTR2AGT | |
| SCHEMBL13037616 | 0.87 | AGTR1 (0.62) | AGTR1AGTR2AGT | |
| SCHEMBL9851520 | 0.86 | AGTR1 (0.57) | AGTR1AGTR2AGT | |
| SCHEMBL9851423 | 0.85 | AGT (0.60) | AGTR1AGTR2AGT | |
| SCHEMBL9195284 | 0.85 | AGTR2 (0.58) | AGTR1AGTR2AGT | |
| SCHEMBL9851408 | 0.85 | AGTR1 (0.56) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL8789482 | 0.84 | AGTR1 (0.61) | AGTR1AGTR2AGTPPARG | |
| SCHEMBL6711100 | 0.84 | AGTR1 (0.59) | AGTR1AGTR2AGT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0392317-B1 | Benzimidazoles, drugs containing these compounds and process for their preparation | THOMAE GMBH DR K (DE) | 1996-01-03 | — | — | EP | disclosed |
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |