Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8389362 | 0.92 | HTR2A (0.41) | NOS1HTR2AGAASLC2A1SLC6A4 | |
| SCHEMBL7756672 | 0.80 | HRH3 (0.38) | HTR2AKDM4EALDH1A1LMNATP53 | |
| SCHEMBL8389373 | 0.78 | HTR7 (0.40) | NOS1HTR2AKDM4EALDH1A1LMNA | |
| SCHEMBL10912768 | 0.75 | MAPT (0.45) | HTR2AKDM4EALDH1A1LMNATP53 | |
| Hydrochloric Acid SCHEMBL20564476 | 0.75 | HTR2A (0.47) | HTR2AHTR1B | |
| Hydrochloric Acid SCHEMBL7373928 | 0.74 | MAPT (0.44) | HTR2AKDM4EALDH1A1LMNATP53 | |
| SCHEMBL8658577 | 0.73 | SLC6A4 (0.38) | SLC6A4 | |
| SCHEMBL8619296 | 0.73 | SLC6A4 (0.38) | KDM4EALDH1A1LMNATP53GAA | |
| SCHEMBL14500336 | 0.73 | KDM4E (0.52) | KDM4EALDH1A1LMNATP53GAA | |
| Hydrochloric Acid SCHEMBL5421079 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1LMNATP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889022-A | Indole, indoline and quinoline derivatives with 5HT1D (anti-depressive) activity | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-03-30 | — | — | US | disclosed |
| EP-0736023-B1 | INDOLE, INDOLINE AND QUINOLINE DERIVATIVES WITH 5HT 1D (ANTI-DEPRESSIVE) ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-07-08 | — | — | EP | disclosed |
| EP-0736023-A1 | INDOLE, INDOLINE AND QUINOLINE DERIVATIVES WITH 5HT 1D? (ANTI-DEPRESSIVE) ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017398-A1 | INDOLE, INDOLINE AND QUINOLINE DERIVATIVES WITH 5HT1D (ANTI-DEPRESSIVE) ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-06-29 | — | — | WO | disclosed |